SpecificfordrebrinisoformsE2andA,widespreadactin-associatingproteinsof70kD(SDS-PAGEmobilityshowsMr120,000).Drebrinhasoriginallybeendescribedonlyinneuronalcells,buthasbeenfoundalsointheactin-richlamellipodiaandfilopodiaofmotilecells.Itisenrichedatjunctionalplaques,definingaspecific
MICROFILamentanchoragesysteminpolarepithelialcells.Negative:hepatocytes,cross-striatedmuscle.